Protein Disordered Region Prediction

PUNCH

A residue-level Intrinsically Disordered Region/Protein (IDP/IDR) predictor trained on PDB and Disprot Databases.

Intrinsically disordered proteins (IDPs) lack stable 3D structures, making computational prediction challenging. PUNCH web server is a fast, lightweight tool with high accuracy, excelling in benchmarks against top predictors on the CAID3 dataset, offering valuable insights for IDP research.

Citation:
Meng, D., & Pollastri, G. (2025). PUNCH2: Explore the strategy for intrinsically disordered protein predictor. PLOS ONE, 20(3), e0319208. https://doi.org/10.1371/journal.pone.0319208
Meng, D., & Pollastri, G. (2025). Punch: An Interactive Web Server for Predicting Intrinsically Disordered Regions in Protein Sequences. J Mol Biol. 2025;169018. doi:10.1016/j.jmb.2025.169018.

Contact us: Di Meng